With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Objective The aim was to examine the general outcome of schizophrenia after 20 years or
more. Methods Using the PRISMA guidelines, we conducted a systematic review and meta …

Abstract The Research Domain Criteria (RDoC) paradigm was launched 10 years ago as a
superior approach for investigation of mental illness. RDoC conceptualizes normal human …

Importance It remains uncertain whether people with psychotic disorders experience
progressive cognitive decline or normal cognitive aging after first hospitalization. This …

BackgroundBipolar disorder (BP) is associated with significant cognitive impairment. Recent
evidence suggests that cognitive deficits are already evident after first-episode mania …

Negative symptoms (such as amotivation and diminished expression) associated with
schizophrenia are a major health concern. Adequate treatment would mean important …

Multidimensional progressive declines in the absence of standard biomarkers for
neurodegeneration are observed commonly in the development of schizophrenia, and are …

Introduction Alterations of verbalized thought occur frequently in psychotic disorders. We
characterize linguistic findings in individuals with schizophrenia based on the current …

One of the critical unmet medical needs in schizophrenia is the treatment for cognitive
deficits. However, the neural circuit mechanisms of them remain unresolved. Previous …

Schizophrenia is a devastating disease that arises on the background of genetic
predisposition and environmental risk factors, such as early life stress (ELS). In this study …