Background The minimum clinically important difference (MCID) is used to interpret the
clinical relevance of results reported by trials and meta-analyses as well as to plan sample …

Background Suitable analgesic drugs and techniques are needed for the acute care of the
approximately 18 200—18 400 seriously injured patients in Germany each year. Methods …

This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

Background Ketamine, as an opium alternative, has been proposed for pain relief in the
emergency department (ED). Objectives This study was carried out to compare low dose …

Background The prevalence of continued opioid use or serious adverse events (SAEs)
following opioid therapy in the emergency department (ED) for musculoskeletal pain is …

Therapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD)
complementary to current pharmacotherapies. The candidate Oxy (Gly) 4-sKLH vaccine …

Aim: To systematically assess and rank the efficacy of opioid medications for traumatic pain
in the emergency department in terms of pain relief, adverse events and rescue analgesia …

Objective: To provide a systematic review of the current role of nebulized fentanyl in acute
pain and potentially other conditions. Data Sources: A MEDLINE literature search inclusive …

Introduction Acute musculoskeletal injuries are one of the most common painful presentation
when admission to the emergency department. The aim of the study is to compare the …

Purpose This article summarizes emerging nontraditional therapies administered via the
nebulization route for use in the emergency department (ED). Summary Although traditional …