Lower and upper respiratory infections are the fourth highest cause of global mortality.
Epidemic and pandemic outbreaks of respiratory infection are a major medical concern …

Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

Influenza viruses belong to the family Orthomyxoviridae with a negative-sense, single-
stranded segmented RNA genome. They infect a wide range of animals, including humans …

Segmented RNA viruses are widespread in nature and include important human, animal
and plant pathogens, such as influenza viruses and rotaviruses. Although the origin of RNA …

How virulence evolves after a virus jumps to a new host species is central to disease
emergence. Our current understanding of virulence evolution is based on insights drawn …

Seasonal and pandemic influenza are the two faces of respiratory infections caused by
influenza viruses in humans. As seasonal influenza occurs on an annual basis, the …

Traditionally, the viral replication cycle is envisioned as a single, well-defined loop with four
major steps: attachment and entry into a target cell, replication of the viral genome …

The resurgence of Ebola virus in the Democratic Republic of the Congo this May is a stark
reminder that no amount of DNA sequencing can tell us when or where the next virus …

Background Canine distemper virus (CDV) is the etiological agent of one of the most
infectious diseases of domestic dogs, also known as a highly prevalent viral infectious …

The patterns and processes of influenza virus evolution are of fundamental importance,
underpinning such traits as the propensity to emerge in new host species and the ability to …