In the era of personalized medicine and targeted therapies for the management of patients
with cancer, ultrasensitive detection methods for tumor genotyping, such as next-generation …

The application of next generation sequencing (NGS) technology to cytological samples has
significantly modified molecular cytopathology practice. Cytological samples represent a …

The previous edition of The Bethesda System for Reporting Thyroid Cytopathology provided
important updates and advances in the practice of thyroid cytopathology. It was inspired by …

Introduction In the current era of personalized medicine, liquid biopsy has acquired a
relevant importance in patient management of advanced stage non-small cell lung cancer …

Background Molecular testing (MT) of thyroid fine‐needle aspiration (FNA)‐derived genetic
material is commonly used to assess malignancy risk for indeterminate cases. The Bethesda …

The vast majority of thyroid cancers originate from follicular cells. We outline outstanding
issues at each step along the path of cancer patient care, from prevention to post-treatment …

Introduction Tumor mutation profiling is standard-of-care in lung carcinoma patients.
However, comprehensive molecular profiling of small specimens, including core needle …

Background Cancer genome profiling of cytology specimens using next‐generation
sequencing (NGS) requires adequate and good‐quality DNA. Genomic examination of …

It is well documented that in the chain from sample to the result in a clinical laboratory, the
pre-analytical phase is the weakest and most vulnerable link. This also holds for the use and …

In patients with thyroid fine-needle aspiration (FNA) report of suspicious for malignancy
(SFM), both lobectomy and thyroidectomy might be considered. BRAF mutation analysis …