The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated
bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent …

T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

Pathophysiology of Inflammatory Bowel Diseases Research on IBDs has identified disrupted
immune responses in the gastrointestinal mucosa and putative disruptions in the gut …

The human gut microbiome is a complex ecosystem that can mediate the interaction of the
human host with their environment. The interaction between gut microbes and commonly …

The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral
diseases remains unclear. Here, we report that periodontal inflammation exacerbates gut …

The need for highly effective vaccines that induce robust and long-lasting immunity has
never been more apparent. However, for reasons that are still poorly understood, immune …

The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …