RNA dependent RNA polymerases: insights from structure, function and evolution
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …
viruses that is indispensable for replicating the genome as well as for carrying out …
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
AJW Te Velthuis, E Fodor - Nature Reviews Microbiology, 2016 - nature.com
The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
Structure of influenza A polymerase bound to the viral RNA promoter
A Pflug, D Guilligay, S Reich, S Cusack - Nature, 2014 - nature.com
The influenza virus polymerase transcribes or replicates the segmented RNA genome (viral
RNA) into viral messenger RNA or full-length copies. To initiate RNA synthesis, the …
RNA) into viral messenger RNA or full-length copies. To initiate RNA synthesis, the …
Antiviral activity exerted by natural products against human viruses
M Musarra-Pizzo, R Pennisi, I Ben-Amor, G Mandalari… - Viruses, 2021 - mdpi.com
Viral infections are responsible for several chronic and acute diseases in both humans and
animals. Despite the incredible progress in human medicine, several viral diseases, such as …
animals. Despite the incredible progress in human medicine, several viral diseases, such as …
Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants
The COVID-19 caused by the SARS-CoV-2 virus was declared a pandemic disease in
March 2020 by the World Health Organization (WHO). Structure-Based Drug Design …
March 2020 by the World Health Organization (WHO). Structure-Based Drug Design …
RNA‐dependent RNA polymerase of SARS‐CoV‐2 as a therapeutic target
Y Wang, V Anirudhan, R Du, Q Cui… - Journal of medical …, 2021 - Wiley Online Library
The global pandemic caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
Structural insight into cap-snatching and RNA synthesis by influenza polymerase
S Reich, D Guilligay, A Pflug, H Malet, I Berger… - Nature, 2014 - nature.com
Influenza virus polymerase uses a capped primer, derived by 'cap-snatching'from host pre-
messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to …
messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to …
Replication of hepatitis C virus
D Moradpour, F Penin, CM Rice - Nature reviews microbiology, 2007 - nature.com
Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …
The ancient Virus World and evolution of cells
Background Recent advances in genomics of viruses and cellular life forms have greatly
stimulated interest in the origins and evolution of viruses and, for the first time, offer an …
stimulated interest in the origins and evolution of viruses and, for the first time, offer an …