[HTML][HTML] Intrinsic dynamics is evolutionarily optimized to enable allosteric behavior
Highlights•The intrinsic dynamics, encoded in proteins' sequences and structures, are
utilized by stimuli to trigger allosteric and functional actions.•The modes of allosteric actions …
utilized by stimuli to trigger allosteric and functional actions.•The modes of allosteric actions …
The “violin model”: Looking at community networks for dynamic allostery
Allosteric regulation of proteins continues to be an engaging research topic for the scientific
community. Models describing allosteric communication have evolved from focusing on …
community. Models describing allosteric communication have evolved from focusing on …
Architecture and self-assembly of the jumbo bacteriophage nuclear shell
Bacteria encode myriad defences that target the genomes of infecting bacteriophage,
including restriction–modification and CRISPR–Cas systems. In response, one family of …
including restriction–modification and CRISPR–Cas systems. In response, one family of …
Extracting Dynamical Correlations and Identifying Key Residues for Allosteric Communication in Proteins by correlationplus
Extracting dynamical pairwise correlations and identifying key residues from large molecular
dynamics trajectories or normal-mode analysis of coarse-grained models are important for …
dynamics trajectories or normal-mode analysis of coarse-grained models are important for …
Revealing the catalytic strategy of FTO
The fat-mass and obesity-associated protein (FTO) is an Fe (II)-and 2-oxoglutarate (2OG)-
dependent oxygenase of the AlkB family and is linked with obesity and cancer. The enzyme …
dependent oxygenase of the AlkB family and is linked with obesity and cancer. The enzyme …
Characterization of differential dynamics, specificity, and allostery of lipoxygenase family members
K Mikulska-Ruminska, I Shrivastava… - Journal of chemical …, 2019 - ACS Publications
Accurate modeling of structural dynamics of proteins and their differentiation across different
species can help us understand generic mechanisms of function shared by family members …
species can help us understand generic mechanisms of function shared by family members …
Ligand-binding-site structure shapes allosteric signal transduction and the evolution of allostery in protein complexes
G Abrusán, JA Marsh - Molecular Biology and Evolution, 2019 - academic.oup.com
The structure of ligand-binding sites has been shown to profoundly influence the evolution of
function in homomeric protein complexes. Complexes with multichain binding sites (MBSs) …
function in homomeric protein complexes. Complexes with multichain binding sites (MBSs) …
Dynamic correlations: exact and approximate methods for mutual information
K Demirtaş, B Erman, T Haliloğlu - Bioinformatics, 2024 - academic.oup.com
Motivation Proteins are dynamic entities that undergo conformational changes critical for
their functions. Understanding the communication pathways and information transfer within …
their functions. Understanding the communication pathways and information transfer within …
[HTML][HTML] Adaptability and specificity: how do proteins balance opposing needs to achieve function?
Many proteins select from a small repertoire of 3-dimensional folds retained over evolutional
timescales and recruited for different functions, with changes in local structure and sequence …
timescales and recruited for different functions, with changes in local structure and sequence …
Quantitative analysis of dynamic Allostery
Dynamic allostery refers to one important class of allosteric regulation that does not involve
noticeable conformational changes upon effector binding. In recent years, many “quasi” …
noticeable conformational changes upon effector binding. In recent years, many “quasi” …