The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Here we define the molecular nature of the mitochondrial permeability transition pore (PTP),
a key effector of cell death. The PTP is regulated by matrix cyclophilin D (CyPD), which also …

For a long time, apoptosis was considered the sole form of programmed cell death during
development, homeostasis and disease, whereas necrosis was regarded as an unregulated …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt
increase in the permeability of the inner mitochondrial membrane to low molecular weight …

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Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough
understanding of apoptotic signaling pathways and insights into apoptosis resistance …

Under conditions of mitochondrial calcium overload, especially when accompanied by
oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a …