Aminoacyl-tRNA synthesis and translational quality control
Translating the 4-letter code of RNA into the 22-letter alphabet of proteins is a central feature
of cellular life. The fidelity with which mRNA is translated during protein synthesis is …
of cellular life. The fidelity with which mRNA is translated during protein synthesis is …
Synthetic and editing mechanisms of aminoacyl-tRNA synthetases
JJ Perona, I Gruic-Sovulj - Aminoacyl-tRNA synthetases in biology and …, 2014 - Springer
Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
Polyamine control of translation elongation regulates start site selection on antizyme inhibitor mRNA via ribosome queuing
Translation initiation is typically restricted to AUG codons, and scanning eukaryotic
ribosomes inefficiently recognize near-cognate codons. We show that queuing of scanning …
ribosomes inefficiently recognize near-cognate codons. We show that queuing of scanning …
Quality control despite mistranslation caused by an ambiguous genetic code
B Ruan, S Palioura, J Sabina… - Proceedings of the …, 2008 - National Acad Sciences
A high level of accuracy during protein synthesis is considered essential for life. Aminoacyl-
tRNA synthetases (aaRSs) translate the genetic code by ensuring the correct pairing of …
tRNA synthetases (aaRSs) translate the genetic code by ensuring the correct pairing of …
The physiological target for Leu RS translational quality control is norvaline
The fidelity of protein synthesis depends on the capacity of aminoacyl‐tRNA synthetases
(AARSs) to couple only cognate amino acid‐tRNA pairs. If amino acid selectivity is …
(AARSs) to couple only cognate amino acid‐tRNA pairs. If amino acid selectivity is …
Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis
BS Shin, T Katoh, E Gutierrez, JR Kim… - Nucleic Acids …, 2017 - academic.oup.com
Whereas ribosomes efficiently catalyze peptide bond synthesis by most amino acids, the
imino acid proline is a poor substrate for protein synthesis. Previous studies have shown that …
imino acid proline is a poor substrate for protein synthesis. Previous studies have shown that …
Cell-specific differences in the requirements for translation quality control
Protein synthesis has an overall error rate of approximately 10-4 for each mRNA codon
translated. The fidelity of translation is mainly determined by two events: synthesis of …
translated. The fidelity of translation is mainly determined by two events: synthesis of …
Homocysteine editing, thioester chemistry, coenzyme A, and the origin of coded peptide synthesis
H Jakubowski - Life, 2017 - mdpi.com
Aminoacyl-tRNA synthetases (AARSs) have evolved “quality control” mechanisms which
prevent tRNA aminoacylation with non-protein amino acids, such as homocysteine …
prevent tRNA aminoacylation with non-protein amino acids, such as homocysteine …
Emergence and evolution
TJ Bullwinkle, M Ibba - Aminoacyl-tRNA synthetases in biology and …, 2014 - Springer
The aminoacyl-tRNA synthetases (aaRSs) are essential components of the protein synthesis
machinery responsible for defining the genetic code by pairing the correct amino acids to …
machinery responsible for defining the genetic code by pairing the correct amino acids to …
Fidelity mechanisms of the aminoacyl-tRNA synthetases
AP Mascarenhas, S An, AE Rosen, SA Martinis… - Protein …, 2009 - Springer
The central dogma and its accurate interpretation by a large array of biomolecules remains a
fascinating process. Understanding its mechanisms of decoding holds tremendous potential …
fascinating process. Understanding its mechanisms of decoding holds tremendous potential …