α-Granules are essential to normal platelet activity. These unusual secretory granules derive
their cargo from both regulated secretory and endocytotic pathways in megakaryocytes …

Summary 22q11. 2 deletion syndrome is characterised by a well defined microdeletion that
is associated with a high risk of neuropsychiatric disorders, including intellectual disability …

Septins are polymerizing GTPases required for cytokinesis and cortical organization. The
principles by which they are targeted to, and assemble at, specific cell regions are unknown …

Septins are an evolutionarily conserved group of GTP‐binding and filament‐forming
proteins that belong to the large superclass of P‐loop GTPases. While originally discovered …

Eukaryotic cells from neurons and epithelial cells to unicellular fungi frequently rely on
cellular appendages such as axons, dendritic spines, cilia, and buds for their biology. The …

Septins are a conserved family of polymerizing guanine nucleotide binding proteins
associated with diverse processes in dividing and non-dividing cells. In humans, 12 septin …

Assembly at the mother–bud neck of a filamentous collar containing five septins (Cdc3,
Cdc10, Cdc11, Cdc12, and Shs1) is necessary for proper morphogenesis and cytokinesis …

Septins are polymerizing GTP binding proteins required for cortical organization during
cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed …

Human septins comprise a family of 13 genes that encode for> 30 protein isoforms with
ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble …

The septins are a conserved family of GTP-binding, filament-forming proteins. In the yeast
Saccharomyces cerevisiae, the septins form a ring at the mother-bud neck that appears to …