Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

There are three dominant contributors to the pathogenesis of dysfunctional adipose tissue
(AT) in obesity: unresolved inflammation, inappropriate extracellular matrix (ECM) …

Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …

Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …

The low efficiency of currently-used anti-cancer therapies poses a serious challenge,
especially in the case of malignant melanoma, a cancer characterized by elevated …

Obesity is one of the most important preventable causes of cancer and the most significant
risk factor for breast cancer in postmenopausal women. Compared with lean women, obese …

Adipocytes are a type of stromal cell found in numerous different tissues that serve an active
role in the tumor microenvironment. Cancer‑associated adipocytes (CAAs) display a …

Growing evidence indicates that adiposity is associated with raised cancer incidence,
morbidity and mortality. In a subset of tumors, cancer cell growth and/or metastasis …

The process of angiogenesis is quite well-known nowadays. Some medicines and extracts
affecting this process are already used routinely in supporting the conventional treatment of …

Obesity is associated with adipose inflammation, defined by macrophages encircling dead
adipocytes, as well as extracellular matrix (ECM) remodeling and increased risk of breast …