One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Adult stem cell populations must coordinate their own maintenance with the generation of
differentiated cell types to sustain organ physiology, in a spatially controlled manner and …

During embryonic development, cells communicate with each other to determine cell fate,
guide migration, and shape morphogenesis. While the relevant secreted factors and their …

Coordination of cell proliferation and migration is fundamental for life, and its dysregulation
has catastrophic consequences, such as cancer. How cell cycle progression affects …

Dynamic contacts between cells within the developing neuroepithelium are poorly
understood but play important roles in cell and tissue morphology and cell signalling. Here …

Ultradian oscillations of HES Transcription Factors (TFs) at the single‐cell level enable cell
state transitions. However, the tissue‐level organisation of HES5 dynamics in neurogenesis …

To reliably form and maintain structures with specific functions, many multicellular systems
evolved to leverage the interplay between biochemical signaling, mechanics, and …

Maintenance of the neural progenitor pool during embryonic development is essential to
promote growth of the central nervous system (CNS). The CNS is initially formed by tightly …

Hes genes are transcriptional repressors activated by Notch. In the developing mouse
neural tissue, HES5 expression oscillates in neural progenitors (Manning et al. 2019 Nat …

Tissue patterning is a critical part of animal development. Here we review the role that length-
and timescales play in shaping patterns during development, focusing on the mechanisms …