Diabetes mellitus (DM) is a metabolic disease that activates several molecular pathways
involved in neurodegenerative disorders. Metformin, an anti-hyperglycemic drug used for …

Metformin is one of the most commonly prescribed antidiabetic drugs. A recent clinical study
has highlighted the protective role of metformin against cardiac complications in type I …

Metformin (MET) is a preferred drug for the treatment of type 2 diabetes mellitus. Recent
studies show that apart from its blood glucose‐lowering effects, it also inhibits the …

Aging is a time-dependent inevitable process, in which cellular homeostasis is affected,
which has an impact on tissue function. This represents a risk factor for the development of …

Scope Alzheimer's disease (AD) is a neurodegenerative disease with phenomena of
cognitive impairments. Oxidative stress and cholinergic system dysfunction are two widely …

Gemfibrozil (GFZ) is a medication of the fibrate category with agonistic effects on peroxisome
proliferator‐activated receptor‐α (PPAR‐α) and is effective for hypertriglyceridemia and …

The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of
reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative …

Metformin (MET), an antidiabetic drug, has shown antioxidative and neuroprotective effects.
In the present investigation, we aimed to study the probable effects of MET on cerebral …

Gemfibrozil (GFZ) is a lipid‐lowering drug with several other effects, such as antioxidant and
anti‐inflammatory activities. In the current study, chronic d‐galactose treatment (d‐gal, 150 …

Background Aging is a phenomenon that all living organisms surely face. d-galactose (D-
gal) has been used to develop an aging model of brain. Lithium (Li) has been proposed to …