Natural small molecules in breast cancer treatment: understandings from a therapeutic viewpoint

MR Islam, F Islam, MH Nafady, M Akter, S Mitra, R Das… - Molecules, 2022 - mdpi.com
Breast cancer (BrCa) is the most common malignancy in women and the second most
significant cause of death from cancer. BrCa is one of the most challenging malignancies to …

Combinatorial epigenetics impact of polyphenols and phytochemicals in cancer prevention and therapy

I Arora, M Sharma, TO Tollefsbol - International journal of molecular …, 2019 - mdpi.com
Polyphenols are potent micronutrients that can be found in large quantities in various food
sources and spices. These compounds, also known as phenolics due to their phenolic …

Natural products for the management and prevention of breast cancer

S Mitra, R Dash - Evidence‐Based Complementary and …, 2018 - Wiley Online Library
Among all types of cancer, breast cancer is one of the most challenging diseases, which is
responsible for a large number of cancer related deaths. Hormonal therapy, surgery …

Biochanin A: A novel bioactive multifunctional compound from nature

A Sarfraz, M Javeed, MA Shah, G Hussain… - Science of the Total …, 2020 - Elsevier
Natural products (NPs) will continue to serve humans as matchless source of novel drug
leads and an inspiration for the synthesis of non-natural drugs. As our scientific …

Reversal of multidrug resistance in cancer by multi-functional flavonoids

Q Ye, K Liu, Q Shen, Q Li, J Hao, F Han… - Frontiers in …, 2019 - frontiersin.org
Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one
of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have …

Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management

AJ Vargas, R Burd - Nutrition reviews, 2010 - academic.oup.com
Quercetin is a unique dietary polyphenol because it can exert biphasic dose-responses on
cells depending on its concentration. Cancer preventative effects of quercetin are observed …

[HTML][HTML] Biochanin A provides neuroprotection against cerebral ischemia/reperfusion injury by Nrf2-mediated inhibition of oxidative stress and inflammation signaling …

M Guo, H Lu, J Qin, S Qu, W Wang, Y Guo… - … medical journal of …, 2019 - ncbi.nlm.nih.gov
Background Oxidative stress and neuroinflammation are 2 pivotal mechanisms in the
progression of cerebral ischemia/reperfusion injury. Biochanin A, a natural phytoestrogen …

Effects and mechanisms of dietary bioactive compounds on breast cancer prevention

K Ganesan, B Du, J Chen - Pharmacological Research, 2022 - Elsevier
Breast cancer (BC) is the most often diagnosed cancer among females globally and has
become an increasing global health issue over the last decades. Despite the substantial …

Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation …

L Kole, B Giri, SK Manna, B Pal, S Ghosh - European journal of …, 2011 - Elsevier
Biochanin-A, an isoflavone, existing in red clover, cabbage and alfalfa, has an inhibitory and
apoptogenic effect on certain cancer cells. However, the actual mechanism by which this …

Risks and benefits of dietary isoflavones for cancer

S Andres, K Abraham, KE Appel… - Critical reviews in …, 2011 - Taylor & Francis
A high intake of fruits and vegetables is associated with a lower risk of cancer. In this context,
considerable attention is paid to Asian populations who consume high amounts of soy and …