Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Artificial intelligence in clinical medicine: catalyzing a sustainable global healthcare paradigm

G Krishnan, S Singh, M Pathania, S Gosavi… - Frontiers in Artificial …, 2023 - frontiersin.org
As the demand for quality healthcare increases, healthcare systems worldwide are
grappling with time constraints and excessive workloads, which can compromise the quality …

Comprehensive proteomics and meta-analysis of COVID-19 host response

H Babačić, W Christ, JE Araújo, G Mermelekas… - Nature …, 2023 - nature.com
COVID-19 is characterised by systemic immunological perturbations in the human body,
which can lead to multi-organ damage. Many of these processes are considered to be …

Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients

E Duijvelaar, J Gisby, JE Peters, HJ Bogaard… - Nature …, 2024 - nature.com
The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

M Essex, B Millet Pascual-Leone, U Löber… - npj Biofilms and …, 2024 - nature.com
The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis
that disease progression and inflammatory responses associate with alterations in the …

A complement atlas identifies interleukin-6–dependent alternative pathway dysregulation as a key druggable feature of COVID-19

KFA Van Damme, L Hoste, J Declercq… - Science Translational …, 2023 - science.org
Improvements in COVID-19 treatments, especially for the critically ill, require deeper
understanding of the mechanisms driving disease pathology. The complement system is not …

Prediction of response to lenvatinib monotherapy for unresectable hepatocellular carcinoma by machine learning radiomics: a multicenter cohort study

Z Bo, B Chen, Z Zhao, Q He, Y Mao, Y Yang, F Yao… - Clinical Cancer …, 2023 - AACR
Purpose: We aimed to construct machine learning (ML) radiomics models to predict
response to lenvatinib monotherapy for unresectable hepatocellular carcinoma (HCC) …

Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19

C Bruzzone, R Conde, N Embade, JM Mato… - Frontiers in Molecular …, 2023 - frontiersin.org
COVID-19 currently represents one of the major health challenges worldwide. Albeit its
infectious character, with onset affectation mainly at the respiratory track, it is clear that the …

Self‐Powered Electrically Controlled Drug Release Systems Based on Nanogenerator

W Luo, R Luo, J Liu, Z Li, Y Wang - Advanced Functional …, 2024 - Wiley Online Library
Precision medicine requires precise regulation of drugs in terms of time, space, and dosage.
Exogenous control systems, such as electrical responsiveness, have made great progress …