Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …

Spatial transcriptomic techniques offer unprecedented insights into the molecular
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …

Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

The selective vulnerability of specific neuronal subtypes is a hallmark of neurodegenerative
diseases. In this Review, I summarize our current understanding of the brain regions and …

The burgeoning interest in in situ multiplexed gene expression profiling technologies has
opened new avenues for understanding cellular behavior and interactions. In this study, we …

Spatial omics technologies characterize tissue molecular properties with spatial information,
but integrating and comparing spatial data across different technologies and modalities is …

The cerebral cortex is composed of neuronal types with diverse gene expression that are
organized into specialized cortical areas. These areas, each with characteristic …

Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …

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Single-cell and single-nucleus genomic approaches can provide unbiased and multimodal
insights. Here, we discuss what constitutes a molecular cell atlas and how to leverage single …