Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to
external cues to regulate the many uses of DNA. A principle component of chromatin that …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Psoriasis is a common inflammatory skin disease involving interactions between
keratinocytes and immune cells that significantly affects the quality of life. It is characterized …

Psoriasis is a chronic, systemic, immune-mediated disease with an incidence of
approximately 2%. The pathogenesis of the disease is complex and not yet fully understood …

Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …

Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a
ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple …

The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …