Abstract Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated
antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play …

Cytokines are key players in the regulation of immune responses both in physiological and
pathological states. A number of cytokines have been evaluated in clinical trials and shown …

Aim of this study was to extend the knowledge on the antineoplastic effect of aloe-emodin
(AE), a natural hydroxyanthraquinone compound, both in metastatic human melanoma cell …

Optimal ex vivo expansion protocols of tumor-specific T cells followed by adoptive cell
therapy must yield T cells able to home to tumors and effectively kill them. Our previous …

Granulocyte-macrophage colony-stimulating factor has been widely used as an adjuvant
therapy for cancer patients exhibiting myelosuppression induced by chemotherapy or …

The use of immune checkpoint inhibitors in patients with metastatic melanoma generates
clinical benefit, including improved survival. Yet disease resistance and immune-related …

The antitumor response after therapeutic vaccination has a limited effect and seems to be
related to the presence of T regulatory cells (Treg), which express the immunoregulatory …

Different diseases lead, during their advanced stages, to chronic or acute liver failure, whose
unique treatment consists in organ transplantation. The success of intervention is limited by …

Most of the cancer treatment strategies from chemotherapy to radiotherapy render cancer
cells apoptotic and these apoptotic cancer cells accumulate at the tumor sites. The …

Whole tumor cell vaccines have shown much promise, but demonstrated poor efficiency in
phase III trials. In this study, we modified MDA-MB‑231 tumor cells (MDA-MB‑231Gal+) to …