In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

The Wnt pathway is a major embryonic signaling pathway that controls cell proliferation, cell
fate, and body-axis determination in vertebrate embryos. Soon after egg fertilization, Wnt …

The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo
development. In mammals, genetic studies have shown that this process relies on signals …

When stimulated with a pulse from an exogenous WNT pathway activator, small aggregates
of mouse embryonic stem cells (ESCs) can undergo embryo-like axial morphogenesis and …

Mammalian hair cells do not regenerate, and their loss is a major cause of deafness. We
recently identified leucine-rich repeat containing, G-protein-coupled receptor 5 (Lgr5) …

The neural crest is a transient and multipotent cell population arising at the edge of the
neural plate in vertebrates. Recent findings highlight that neural crest patterning is initiated …

The canonical Wnt/β-catenin signaling pathway is known to play crucial roles in
organogenesis by regulating both proliferation and differentiation. In the inner ear, this …

The recent identification of multiple dominant mutations in the gene encoding β-catenin in
both humans and mice has enabled exploration of the molecular and cellular basis of β …

Morphogenesis of mammalian facial processes requires coordination of cellular
proliferation, migration, and apoptosis to develop intricate features. Cleft lip and/or palate …

The Wnt signaling pathway plays key roles in differentiation and development and
alterations in this signaling pathway are causally associated with numerous human …