The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Background The molecular determinants of clinical responses to decitabine therapy in
patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are …

Selectins are vascular adhesion molecules that mediate physiological responses such as
inflammation, immunity and hemostasis. During cancer progression, selectins promote …

T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% and 25% of total childhood
and adult ALL cases, respectively. During T-ALL, patients are at risk of organ infiltration by …

Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a
role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids …

In chronic lymphocytic leukemia (CLL), increasing knowledge of the biology of the tumor
cells has led to transformative improvements in our capacity to assess and treat patients …

Chronic lymphocytic leukemia (CLL) cells extensively interact with and depend on their
surrounding tumor microenvironment (TME). The TME encompasses a heterogeneous array …

Recirculation of chronic lymphocytic leukemia (CLL) cells between the peripheral blood and
lymphoid niches plays a critical role in disease pathophysiology, and inhibiting this process …

The trafficking of neoplastic cells represents a key process that contributes to progression of
hematologic malignancies. Diapedesis of neoplastic cells across endothelium and …