Individuals with Down syndrome (DS) commonly possess unique neurocognitive and
neurobehavioral profiles that emerge within specific developmental periods. These profiles …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

This chapter reviews the neurological phenotype of Down syndrome (DS) in early
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …

Down syndrome (DS) is one of the most well-recognized genetic disorders. Persons with DS
are known to have a variety of co-morbid medical problems, affecting nearly all organ …

Down syndrome (DS) is a form of accelerated aging, and people with DS are highly prone to
aging-related conditions that include vascular and neurological disorders. Due to the …

The mechanisms of epileptogenesis in pediatric epileptic syndromes are diverse, and may
involve disturbances of neurodevelopmental trajectories, synaptic homeostasis, and cortical …

Objective To describe the electroclinical features and the long-term outcomes of epilepsy in
a large cohort of males and females with Down syndrome who developed epilepsy in …

Objectives. To evaluate infantile spasms in children with Down syndrome including
assessment of efficacy of treatments, presence of treatment lag, and to identify risk factors …

Objective: We performed a retrospective chart review of patients with trisomy 21 and infantile
spasms in our university-based pediatric epilepsy center between 2002 and 2016 in order to …

Down syndrome (DS) is one of the most common causes of mental retardation in children.
Many children with DS suffer from neurologic problems, including seizures. Epileptic spasms …