[HTML][HTML] Structural basis of Keap1 interactions with Nrf2
P Canning, FJ Sorrell, AN Bullock - Free Radical Biology and Medicine, 2015 - Elsevier
Keap1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the
Cul3 protein to form a Cullin–RING E3 ligase complex for the degradation of Nrf2. Oxidative …
Cul3 protein to form a Cullin–RING E3 ligase complex for the degradation of Nrf2. Oxidative …
Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation
In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …
[HTML][HTML] The molecular basis of JAK/STAT inhibition by SOCS1
The SOCS family of proteins are negative-feedback inhibitors of signalling induced by
cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by …
cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by …
[HTML][HTML] The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
Abstract Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer
and inflammatory disease, and initiates potent innate immune responses through the …
and inflammatory disease, and initiates potent innate immune responses through the …
[HTML][HTML] Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
K Baek, DC Scott, LT Henneberg, MT King, M Mann… - Cell, 2023 - cell.com
Cells respond to environmental cues by remodeling their inventories of multiprotein
complexes. Cellular repertoires of SCF (SKP1-CUL1-F box protein) ubiquitin ligase …
complexes. Cellular repertoires of SCF (SKP1-CUL1-F box protein) ubiquitin ligase …
Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif
Y Guo, L Dong, X Qiu, Y Wang, B Zhang, H Liu, Y Yu… - Nature, 2014 - nature.com
The human immunodeficiency virus (HIV)-1 protein Vif has a central role in the neutralization
of host innate defences by hijacking cellular proteasomal degradation pathways to subvert …
of host innate defences by hijacking cellular proteasomal degradation pathways to subvert …
[HTML][HTML] Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex
Cullin RING E3 ubiquitin ligases (CRLs) function in the ubiquitin proteasome system to
catalyze the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins …
catalyze the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins …
BTB domains: a structural view of evolution, multimerization, and protein–protein interactions
A Bonchuk, K Balagurov, P Georgiev - Bioessays, 2023 - Wiley Online Library
Abstract Broad‐complex, Tramtrack, and Bric‐à‐brac/poxvirus and zinc finger (BTB/POZ) is
a conserved domain found in many eukaryotic proteins with diverse cellular functions …
a conserved domain found in many eukaryotic proteins with diverse cellular functions …
Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life
K Yumimoto, S Sugiyama, S Motomura… - Science …, 2023 - science.org
Reactive oxygen species (ROS) posed a risk for the transition of vertebrates from aquatic to
terrestrial life. How ancestral organisms adapted to such ROS exposure has remained a …
terrestrial life. How ancestral organisms adapted to such ROS exposure has remained a …
[HTML][HTML] Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H
Abstract Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are
particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity …
particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity …