The B7: CD28 family and friends: Unraveling coinhibitory interactions
KP Burke, A Chaudhri, GJ Freeman, AH Sharpe - Immunity, 2024 - cell.com
Immune responses must be tightly regulated to ensure both optimal protective immunity and
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …
MicroRNAs as regulators of immune checkpoints in cancer immunotherapy: targeting PD-1/PD-L1 and CTLA-4 pathways
A Zabeti Touchaei, S Vahidi - Cancer Cell International, 2024 - Springer
Immunotherapy has revolutionized cancer treatment by harnessing the power of the immune
system to eliminate tumors. Immune checkpoint inhibitors (ICIs) block negative regulatory …
system to eliminate tumors. Immune checkpoint inhibitors (ICIs) block negative regulatory …
CD8+ T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs
Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves
antitumor immune responses in preclinical studies, clinical success has been limited by on …
antitumor immune responses in preclinical studies, clinical success has been limited by on …
Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response
H Qi, Z Sun, T Gao, Y Yao, Y Wang, W Li, X Wang… - Molecular Cancer, 2024 - Springer
Nucleic acid vaccines have shown promising potency and efficacy for cancer treatment with
robust and specific T-cell responses. Improving the immunogenicity of delivered antigens …
robust and specific T-cell responses. Improving the immunogenicity of delivered antigens …
CD40 agonism improves anti-tumor T cell priming induced by the combination of radiation therapy plus CTLA4 inhibition and enhances tumor response
M Charpentier, S Formenti, S Demaria - Oncoimmunology, 2023 - Taylor & Francis
Radiation therapy (RT) combined with CTLA4 blockers converts immunosuppressed (cold)
mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have …
mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have …
FcγRIIB is an immune checkpoint limiting the activity of treg-targeting antibodies in the tumor microenvironment
DA Knorr, L Blanchard, RS Leidner, SM Jensen… - Cancer immunology …, 2024 - AACR
Preclinical murine data indicate that fragment crystallizable (Fc)-dependent depletion of
intratumoral regulatory T cells (Treg) is a major mechanism of action of anti–CTLA-4 …
intratumoral regulatory T cells (Treg) is a major mechanism of action of anti–CTLA-4 …
Resident memory T cells and cancer
NV Gavil, K Cheng, D Masopust - Immunity, 2024 - cell.com
Tissue-resident memory T (T RM) cells positively correlate with cancer survival, but the anti-
tumor mechanisms underlying this relationship are not understood. This review reconciles …
tumor mechanisms underlying this relationship are not understood. This review reconciles …
Immunotherapy for hepatocellular carcinoma: the next evolution in expanding access to liver transplantation
M Li, S Bhoori, N Mehta, V Mazzaferro - Journal of Hepatology, 2024 - Elsevier
Immunotherapy has revolutionized treatment of advanced hepatocellular carcinoma (HCC).
In addition, several phase III trials of immunotherapy in early-to intermediate-stage HCC in …
In addition, several phase III trials of immunotherapy in early-to intermediate-stage HCC in …
[HTML][HTML] TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor …
F Azar, J Deforges, C Demeusoit… - … for Immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Background TG6050 was designed as an improved oncolytic vector, combining the intrinsic
properties of vaccinia virus to selectively replicate in tumors with the tumor-restricted …
properties of vaccinia virus to selectively replicate in tumors with the tumor-restricted …
Regulatory T Cells Require AMP-Activated Protein Kinase to Sustain Their Function in Pathological Settings Characterized by Microenvironmental Stress
MAT Acosta - 2024 - search.proquest.com
Abstract CD4+ FOXP3+ regulatory T (Treg) cells maintain self-tolerance, suppress the
immune response to cancer, and protect against tissue injury in the lung and other organs …
immune response to cancer, and protect against tissue injury in the lung and other organs …