The global COVID-19 pandemic has the potential to severely affect those with rheumatic
diseases or who are taking immunosuppressive therapies. Information is lacking as to how …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic,
environmental, and immunologic factors. Posttranslational modifications (PTMs) such as …

The generation of post-translational modifications (PTMs) in human proteins is a
physiological process leading to structural and immunologic variety in proteins, with …

In RA patients' synovial sites, citrullinated RA-related antigens such as type II collagens,
fibrin (ogen), vimentin, and α-enolase could be targeted by ACCPAs. Since ACCPA …

Protein arginine deimination leading to the non-coded amino acid citrulline remains a key
question in the field of post-translational modifications ever since its discovery by Rogers …

Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the
breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis. This reaction is …

Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated
protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients. Apart from their …

Rationale: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are
important regulators of inflammation. The exact impact of ROS/RNS on cutaneous delayed …

Peptidylarginine deiminases (PADs) are a group of enzymes that catalyze post-translational
modifications of proteins by converting arginine residues into citrullines. Among the five …