Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …

Despite the high incidence of inner ear disorders, there are still no dedicated medications on
the market. Drugs are currently administered by the intratympanic route, the safest way to …

Sensorineural hearing loss (SNHL) can be overcome by electrical stimulation of spiral
ganglion neurons (SGNs) via a cochlear implant (CI). Restricted CI performance results from …

Amniotes evolved a unique postsynaptic terminal in the inner ear vestibular organs called
the calyx that receives both quantal and nonquantal (NQ) synaptic inputs from Type I …

There are a number of psychophysical and electrophysiological measures that are
correlated with SGN density in animal models, and these same measures can be performed …

Hearing loss impacts the quality of life and affects communication resulting in social isolation
and reduced well-being. Despite its impact on society and economy, no therapies for age …

Background: The success of a cochlear implant (CI), which is the standard therapy for
patients suffering from severe to profound sensorineural hearing loss, depends on the …

Noise-induced hearing loss (NIHL) is one of the most prevalent acquired sensorineural
hearing loss etiologies and is characterized by the loss of cochlear hair cells, synapses, and …

TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent
cochlear synapses after noise-induced synaptopathy. The effects were consistent with …

Drug delivery to the inner ear is an ideal method to treat a wide variety of otologic conditions.
A broad range of potential applications is just beginning to be explored. New approaches …