Context Bladder cancer (BC) represents a significant health problem due to the potential
morbidity and mortality associated with disease burden, which has remained largely …

Bladder cancer is among the ten most common cancers globally, causes considerable
morbidity and mortality and is, therefore, a substantial burden for health-care systems. The …

Historically, professional society guidelines have recommended limited genetic testing for
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …

Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and
associated with a poor prognosis. With a high mutation load and large number of altered …

Background ATLAS evaluated the efficacy and safety of the PARP inhibitor rucaparib in
patients with previously treated locally advanced/unresectable or metastatic urothelial …

Backgrounds Despite the genomic landscape of urothelial carcinomas (UC) patients,
especially those with UC of bladder (UCB), has been comprehensively delineated and …

The prevalence and biological consequences of deleterious germline variants in urothelial
cancer (UC) are not fully characterized. We performed whole-exome sequencing (WES) of …

Bladder cancer (BC) is characterized by significant histopathologic and molecular
heterogeneity. The discovery of molecular pathways and knowledge of cellular mechanisms …

The fishing cat, Prionailurus viverrinus, faces a population decline, increasing the
importance of maintaining healthy zoo populations. Unfortunately, zoo-managed individuals …

Background: High-fidelity repair of DNA damage repair (DDR)(either single-strand-[SSBs] or
double-strand breaks [DSBs]) is necessary for maintaining genomic integrity and cell …