Botulinum neurotoxins: biology, pharmacology, and toxicology
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature
Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven
serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin …
serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin …
Identification and characterization of a novel botulinum neurotoxin
Botulinum neurotoxins are known to have seven serotypes (BoNT/A–G). Here we report a
new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with …
new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with …
Botulinum and tetanus neurotoxins
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins
known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as …
known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as …
[HTML][HTML] Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium
Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of
potent bacterial toxins and potential bioterrorism agents. Here we report that an …
potent bacterial toxins and potential bioterrorism agents. Here we report that an …
Bacterial signaling to the nervous system through toxins and metabolites
NJ Yang, IM Chiu - Journal of molecular biology, 2017 - Elsevier
Mammalian hosts interface intimately with commensal and pathogenic bacteria. It is
increasingly clear that molecular interactions between the nervous system and microbes …
increasingly clear that molecular interactions between the nervous system and microbes …
Clinical uses of botulinum neurotoxins: current indications, limitations and future developments
S Chen - Toxins, 2012 - mdpi.com
Botulinum neurotoxins (BoNTs) cause flaccid paralysis by interfering with vesicle fusion and
neurotransmitter release in the neuronal cells. BoNTs are the most widely used therapeutic …
neurotransmitter release in the neuronal cells. BoNTs are the most widely used therapeutic …
PET imaging of synaptic density: a new tool for investigation of neuropsychiatric diseases
Synaptic vesicle glycoprotein 2A (SV2A) is expressed ubiquitously in neurons of the central
nervous system, and is the binding target of the anti-epileptic drug levetiracetam. Because of …
nervous system, and is the binding target of the anti-epileptic drug levetiracetam. Because of …
Synaptic vesicle glycoprotein 2A: features and functions
In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …
expeditious development of specific radioligands of novel targets. Among these targets, the …
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
A Yamagata, K Ito, T Suzuki, N Dohmae… - Nature …, 2024 - nature.com
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a
successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV) …
successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV) …