Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

Indazolium trans-[tetrachlorobis (1H-indazole) ruthenate (III)](KP1019 or FFC14A) is just the
second ruthenium-based anticancer agent after NAMI-A which was developed to the stage …

1, 2, 4-triazole is an important nucleus present in a large number of compounds. More than
thirty-five compounds containing this nucleus are introduced into the market. 1, 2, 4-triazole …

A series of metal complexes of Co (II), Ni (II), Cu (II) and Zn (II) have been synthesized with
newly prepared biologically active ligands. These ligands were prepared by the …

An alternative sequence of bioactive series, using novel Schiff base derivative (1-Quinolin-8-
yliminomethyl-naphthalen-2-ol), was produced (HNQ). Elements analysis, molar …

DNA is believed to be the primary target for many metal-based drugs. For example, platinum-
based anticancer drugs can form specific lesions on DNA that induce apoptosis. New …

Platinum (II)-based anticancer drugs play an essential role in the clinic today, and a number
of coordination compounds with other metals are in current development as promising …

Organometallic complexes offer potential for design as anticancer drugs. They can act as
inert scaffolds and specifically inhibit enzymes such as kinases, or as pro-drugs which …

Imidazolium [trans-tetrachloro (1 H-imidazole)(S-dimethylsulfoxide) ruthenate (III)](NAMI-A)
and indazolium [trans-tetrachlorobis (1 H-indazole) ruthenate (III)](KP1019) are the most …

Bis-Schiff bases 1–27 have been synthesized and their in vitro antiglycation potential has
been evaluated. Compounds 21 (IC50= 243.95±4.59 μM), 20 (IC50= 257.61±5.63 μM), and …