Novel insights in systemic lupus erythematosus and atherosclerosis

V Teixeira, LS Tam - Frontiers in Medicine, 2018 - frontiersin.org
Introduction The systemic inflammatory nature of systemic lupus erythematosus (SLE) is well
patent not only in the diverse clinical manifestations of the disease but also in the increased …

The pathophysiology of hypertension in systemic lupus erythematosus.

MJ Ryan - American journal of physiology. Regulatory, integrative …, 2009 - europepmc.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disorder that
predominantly affects women during their reproductive years. Although SLE can affect any …

Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors

M Szekeres, GL Nádasy, G Turu… - Journal of Biological …, 2012 - ASBMB
In the vascular system angiotensin II (Ang II) causes vasoconstriction via the activation of
type 1 angiotensin receptors. Earlier reports have shown that in cellular expression systems …

Beneficial effects of rapamycin on endothelial function in systemic lupus erythematosus

H Kim, MP Massett - Frontiers in Physiology, 2024 - frontiersin.org
Introduction Endothelial function is significantly impaired in patients with SLE compared to
healthy controls. Elevated activation of the mammalian target of rapamycin complex 1 …

Effects of aerobic exercise training on ACE and ADRB2 gene expression, plasma angiotensin II level, and flow-mediated dilation: a study on obese postmenopausal …

N Azadpour, B Tartibian, ŞN Koşar - Menopause, 2017 - journals.lww.com
Objective: The purpose of this study is to determine the effect of 10 weeks of moderate-
intensity aerobic exercise training (MIET) on blood pressure (BP), angiotensin-converting …

Elevated systemic TGF-β impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial …

A Buday, P Orsy, M Godó, M Mózes… - American Journal …, 2010 - journals.physiology.org
The role of circulating, systemic TGF-β levels in endothelial function is not clear. TGF-β1 may
cause endothelial dysfunction in apolipoprotein E-deficient (apoE−/−) mice via stimulation of …

The role of zinc and copper in platelet activation and pathophysiological thrombus formation in patients with pulmonary embolism in the course of SARS-CoV-2 …

M Szewc, A Markiewicz-Gospodarek, A Gorska… - Biology, 2022 - mdpi.com
Simple Summary Recent studies associated COVID-19 with coagulation dysfunction and
increased risk of thromboembolism. Consequently, pulmonary embolism (PE) development …

Blood pressure and renal hemodynamic responses to acute angiotensin II infusion are enhanced in a female mouse model of systemic lupus erythematosus

M Venegas-Pont, KW Mathis, R Iliescu… - American Journal …, 2011 - journals.physiology.org
Inflammation and immune system dysfunction contributes to the development of
cardiovascular and renal disease. Systemic lupus erythematosus (SLE) is a chronic …

Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide

K Imaruoka, Y Oe, T Fushima, E Sato… - Biochemical and …, 2019 - Elsevier
Systemic lupus erythematosus (SLE) increases the risk of preterm birth and preeclampsia
(PE). The flares of SLE during pregnancy or after delivery are also problematic. We have …

ANG II facilitated CD11+Ly6Chi cells reprogramming into M1-like macrophage through Erk1/2 or p38-Stat3 pathway and involved in EAM

H Lu, Y Wu, X Shao, S Zhou, Y Jiang… - Journal of Leukocyte …, 2018 - academic.oup.com
Macrophage, a highly plastic population, is widely distributed. Macrophage functions are
settled and acquired polarization programs in response to microenvironmental signals and …