[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …
in a non-disruptive and non-invasive manner. The obtained molecular properties at …
NMR crystallography of molecular organics
P Hodgkinson - Progress in Nuclear Magnetic Resonance …, 2020 - Elsevier
Developments of NMR methodology to characterise the structures of molecular organic
structures are reviewed, concentrating on the previous decade of research in which density …
structures are reviewed, concentrating on the previous decade of research in which density …
Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques
E Pindelska, A Sokal, W Kolodziejski - Advanced drug delivery reviews, 2017 - Elsevier
The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …
Dynamic nuclear polarization enhanced NMR spectroscopy for pharmaceutical formulations
AJ Rossini, CM Widdifield, A Zagdoun… - Journal of the …, 2014 - ACS Publications
Dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy at 9.4 T is
demonstrated for the detailed atomic-level characterization of commercial pharmaceutical …
demonstrated for the detailed atomic-level characterization of commercial pharmaceutical …
Structural and dynamic properties of amorphous solid dispersions: the role of solid-state nuclear magnetic resonance spectroscopy and relaxometry
A Paudel, M Geppi, G Van den Mooter - Journal of pharmaceutical …, 2014 - Elsevier
Amorphous solid dispersions (ASDs) are one of the frontier strategies to improve solubility
and dissolution rate of poorly soluble drugs and hence tackling the growing challenges in …
and dissolution rate of poorly soluble drugs and hence tackling the growing challenges in …
Proton detection of MAS solid-state NMR spectra of half-integer quadrupolar nuclei
Fast magic angle spinning (MAS) and proton detection has found widespread application to
enhance the sensitivity of solid-state NMR experiments with spin-1/2 nuclei such as 13 C, 15 …
enhance the sensitivity of solid-state NMR experiments with spin-1/2 nuclei such as 13 C, 15 …
Molecular interactions in posaconazole amorphous solid dispersions from two-dimensional solid-state NMR spectroscopy
Molecular interactions between the active pharmaceutical ingredient and polymer have
potentially substantial impacts on the physical stability of amorphous solid dispersions …
potentially substantial impacts on the physical stability of amorphous solid dispersions …
DNP‐enhanced solid‐state NMR spectroscopy of active pharmaceutical ingredients
Solid‐state NMR spectroscopy has become a valuable tool for the characterization of both
pure and formulated active pharmaceutical ingredients (APIs). However, NMR generally …
pure and formulated active pharmaceutical ingredients (APIs). However, NMR generally …
17O NMR studies of organic and biological molecules in aqueous solution and in the solid state
G Wu - Progress in Nuclear Magnetic Resonance …, 2019 - Elsevier
This review describes the latest developments in the field of 17 O NMR spectroscopy of
organic and biological molecules both in aqueous solution and in the solid state. In the first …
organic and biological molecules both in aqueous solution and in the solid state. In the first …
Probing O–H Bonding through Proton Detected 1H–17O Double Resonance Solid-State NMR Spectroscopy
The ubiquity of oxygen in organic, inorganic, and biological systems has stimulated the
application and development of 17O solid-state NMR spectroscopy as a probe of molecular …
application and development of 17O solid-state NMR spectroscopy as a probe of molecular …