Nanotechnology as a novel approach in combating microbes providing an alternative to antibiotics
The emergence of infectious diseases promises to be one of the leading mortality factors in
the healthcare sector. Although several drugs are available on the market, newly found …
the healthcare sector. Although several drugs are available on the market, newly found …
Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société …
R Guilhaumou, S Benaboud, Y Bennis… - Critical Care, 2019 - Springer
Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
From therapeutic drug monitoring to model‐informed precision dosing for antibiotics
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
Cefepime-induced neurotoxicity: a systematic review
Background Cefepime is a widely used antibiotic with neurotoxicity attributed to its ability to
cross the blood–brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid …
cross the blood–brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid …
Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)
Background Early and appropriate antibiotic dosing is associated with improved clinical
outcomes in critically ill patients, yet target attainment remains a challenge. Traditional …
outcomes in critically ill patients, yet target attainment remains a challenge. Traditional …
[HTML][HTML] Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study
L Boschung-Pasquier, A Atkinson, LK Kastner… - Clinical microbiology …, 2020 - Elsevier
Objectives Toxic serum cefepime trough concentrations are not well defined in the current
literature. We aimed to define a more precise plasma trough concentration threshold for this …
literature. We aimed to define a more precise plasma trough concentration threshold for this …
[HTML][HTML] Model-informed precision dosing: State of the art and future perspectives
IK Minichmayr, E Dreesen, M Centanni, Z Wang… - Advanced drug delivery …, 2024 - Elsevier
Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
Clinical pharmacokinetics and pharmacodynamics of cefepime
Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against Gram-
positive and Gram-negative pathogens. It is generally administered as an infusion over 30 …
positive and Gram-negative pathogens. It is generally administered as an infusion over 30 …
Therapeutic drug monitoring of beta-lactams and other antibiotics in the intensive care unit: which agents, which patients and which infections?
Antibiotics are among the medications most frequently administered to the critically ill, a
population with high levels of intra-and inter-individual pharmacokinetic variability. Our …
population with high levels of intra-and inter-individual pharmacokinetic variability. Our …
Setting the beta-lactam therapeutic range for critically ill patients: is there a floor or even a ceiling?
OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …
concentrations in patients with critical illness which led to an interest in the use of …