Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic
feature of more than 20 degenerative conditions affecting either the central nervous system …

Short peptides are uniquely versatile building blocks for self-assembly. Supramolecular
peptide assemblies can be used to construct functional hydrogel biomaterials—an attractive …

The amyloid peptides Aβ40 and Aβ42 of Alzheimer's disease are thought to contribute
differentially to the disease process. Although Aβ42 seems more pathogenic than Aβ40, the …

The aggregation of proteins is central to many aspects of daily life, including food
processing, blood coagulation, eye cataract formation disease and prion-related …

The aggregation of proteins is of fundamental relevance in a number of daily phenomena,
as important and diverse as blood coagulation, medical diseases, or cooking an egg in the …

This review summarises our current understanding of the underlying and universal
mechanism by which newly synthesised proteins achieve their biologically functional states …

The ability of proteins to fold to their functional states following synthesis in the intracellular
environment is one of the most remarkable features of biology. Substantial progress has …

Under solution conditions where the native state is destabilized, the largely helical
polypeptide hormone insulin readily aggregates to form amyloid fibrils with a characteristic …

Motivation: Amyloidogenic regions in polypeptide chains are very important because such
regions are responsible for amyloid formation and aggregation. It is useful to be able to …