Envelope stress responses: balancing damage repair and toxicity
AM Mitchell, TJ Silhavy - Nature Reviews Microbiology, 2019 - nature.com
The Gram-negative envelope is a complex structure that consists of the inner membrane, the
periplasm, peptidoglycan and the outer membrane, and protects the bacterial cell from the …
periplasm, peptidoglycan and the outer membrane, and protects the bacterial cell from the …
A comparative view of metabolite and substrate stress and tolerance in microbial bioprocessing: from biofuels and chemicals, to biocatalysis and bioremediation
SA Nicolaou, SM Gaida, ET Papoutsakis - Metabolic engineering, 2010 - Elsevier
Metabolites, substrates and substrate impurities may be toxic to cells by damaging biological
molecules, organelles, membranes or disrupting biological processes. Chemical stress is …
molecules, organelles, membranes or disrupting biological processes. Chemical stress is …
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane.
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
[HTML][HTML] Damage dynamics and the role of chance in the timing of E. coli cell death
Genetically identical cells in the same stressful condition die at different times. The origin of
this stochasticity is unclear; it may arise from different initial conditions that affect the time of …
this stochasticity is unclear; it may arise from different initial conditions that affect the time of …
Small cationic antimicrobial peptides delocalize peripheral membrane proteins
Short antimicrobial peptides rich in arginine (R) and tryptophan (W) interact with
membranes. To learn how this interaction leads to bacterial death, we characterized the …
membranes. To learn how this interaction leads to bacterial death, we characterized the …
Mini review: bacterial membrane composition and its modulation in response to stress
JR Willdigg, JD Helmann - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Antibiotics and other agents that perturb the synthesis or integrity of the bacterial cell
envelope trigger compensatory stress responses. Focusing on Bacillus subtilis as a model …
envelope trigger compensatory stress responses. Focusing on Bacillus subtilis as a model …
Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure
Recent research has disclosed a tight connection between obesity, metabolic gut microbial
activities and host health. Obtaining a complete understanding of this relationship remains a …
activities and host health. Obtaining a complete understanding of this relationship remains a …
Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily
Membrane remodeling and repair are essential for all cells. Proteins that perform these
functions include Vipp1/IM30 in photosynthetic plastids, PspA in bacteria, and ESCRT-III in …
functions include Vipp1/IM30 in photosynthetic plastids, PspA in bacteria, and ESCRT-III in …
Global Analysis of Extracytoplasmic Stress Signaling in Escherichia coli
S Bury-Moné, Y Nomane, N Reymond, R Barbet… - PLoS …, 2009 - journals.plos.org
The Bae, Cpx, Psp, Rcs, and σE pathways constitute the Escherichia coli signaling systems
that detect and respond to alterations of the bacterial envelope. Contributions of these …
that detect and respond to alterations of the bacterial envelope. Contributions of these …
Managing membrane stress: the phage shock protein (Psp) response, from molecular mechanisms to physiology
The bacterial phage shock protein (Psp) response functions to help cells manage the
impacts of agents impairing cell membrane function. The system has relevance to …
impacts of agents impairing cell membrane function. The system has relevance to …