[HTML][HTML] Dorsal root ganglion infiltration by macrophages contributes to paclitaxel chemotherapy-induced peripheral neuropathy
H Zhang, Y Li, M de Carvalho-Barbosa, A Kavelaars… - The journal of pain, 2016 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a disruptive and persistent side
effect of cancer treatment with paclitaxel. Recent reports showed that paclitaxel treatment …
effect of cancer treatment with paclitaxel. Recent reports showed that paclitaxel treatment …
[HTML][HTML] Peripheral neuropathic pain: from experimental models to potential therapeutic targets in dorsal root ganglion neurons
TY Yeh, IW Luo, YL Hsieh, TJ Tseng, H Chiang… - Cells, 2020 - mdpi.com
Neuropathic pain exerts a global burden caused by the lesions in the somatosensory nerve
system, including the central and peripheral nervous systems. The mechanisms of nerve …
system, including the central and peripheral nervous systems. The mechanisms of nerve …
[HTML][HTML] Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral …
H Zhang, JA Boyette-Davis, AK Kosturakis, Y Li… - The journal of pain, 2013 - Elsevier
The use of paclitaxel (Taxol), a microtubule stabilizer, for cancer treatment is often limited by
its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]) …
its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]) …
[HTML][HTML] Hedgehog signaling regulates nociceptive sensitization
DT Babcock, S Shi, J Jo, M Shaw, HB Gutstein… - Current Biology, 2011 - cell.com
Background Nociceptive sensitization is a tissue damage response whereby sensory
neurons near damaged tissue enhance their responsiveness to external stimuli. This …
neurons near damaged tissue enhance their responsiveness to external stimuli. This …
[HTML][HTML] CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord
W Shen, XM Hu, YN Liu, Y Han, LP Chen… - Journal of …, 2014 - Springer
Background Previous studies have demonstrated that chemokine CXCL12 and its receptor
CXCR4 are critical for pain sensitization, but the mechanisms involved are not clear. In this …
CXCR4 are critical for pain sensitization, but the mechanisms involved are not clear. In this …
Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses
YX Chu, Y Zhang, YQ Zhang, ZQ Zhao - Brain, behavior, and immunity, 2010 - Elsevier
Tetanic stimulation of the sciatic nerve (TSS) produces long-term potentiation (LTP) of C-
fiber-evoked field potentials in the spinal cord. This potentiation is considered to be a …
fiber-evoked field potentials in the spinal cord. This potentiation is considered to be a …
Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation
P Liu, J Cheng, S Ma, J Zhou - Inflammopharmacology, 2020 - Springer
Neuropathic pain remains one of the most common pain conditions worldwide.
Accumulating evidence shows that activation of the NOD-like receptor protein 3 (NLRP3) …
Accumulating evidence shows that activation of the NOD-like receptor protein 3 (NLRP3) …
Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture
L Vulchanova, DJ Schuster, LR Belur… - Molecular …, 2010 - journals.sagepub.com
Background: Neuronal transduction by adeno-associated viral (AAV) vectors has been
demonstrated in cortex, brainstem, cerebellum, and sensory ganglia. Intrathecal delivery of …
demonstrated in cortex, brainstem, cerebellum, and sensory ganglia. Intrathecal delivery of …
[HTML][HTML] β-Hydroxybutyrate Attenuates Painful Diabetic Neuropathy via Restoration of the Aquaporin-4 Polarity in the Spinal Glymphatic System
F Wang, C Xu, C Su, J Li, J Lin - Frontiers in neuroscience, 2022 - frontiersin.org
Waste removal is essential for maintaining homeostasis and the normal function of the
central nervous system (CNS). The glymphatic system based on aquaporin-4 (AQP4) water …
central nervous system (CNS). The glymphatic system based on aquaporin-4 (AQP4) water …
Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats
ZF Wang, Q Li, SB Liu, WL Mi, S Hu, J Zhao, Y Tian… - Neuroscience, 2014 - Elsevier
Abstract Aspirin-triggered Lipoxin A 4 (ATL), as a Lipoxin A 4 (LXA 4) epimer, is
endogenously produced by aspirin-acetylated cycloxygenase-2 (COX-2) and plays a vital …
endogenously produced by aspirin-acetylated cycloxygenase-2 (COX-2) and plays a vital …