[HTML][HTML] Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
SE Polo, SP Jackson - Genes & development, 2011 - genesdev.cshlp.org
Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …
termed the DNA damage response (DDR). A common feature of DDR proteins is their …
[PDF][PDF] Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
[HTML][HTML] Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer
Papillary thyroid carcinoma (PTC) demonstrates significantly reduced patient survival with
metastatic progression. Tumor progression can be influenced by metabolism, including …
metastatic progression. Tumor progression can be influenced by metabolism, including …
[HTML][HTML] NPM1/B23: a multifunctional chaperone in ribosome biogenesis and chromatin remodeling
MS Lindström - Biochemistry research international, 2011 - hindawi.com
At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …
processes, but they share a common problem involving interactions between charged …
Nucleolus: a central hub for nuclear functions
The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …
far from being comprehensively understood. Much work on the nucleolus has focused on its …
The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis
MA Farg, A Konopka, KY Soo, D Ito… - Human molecular …, 2017 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease
affecting motor neurons. Hexanucleotide (GGGGCC) repeat expansions in a non-coding …
affecting motor neurons. Hexanucleotide (GGGGCC) repeat expansions in a non-coding …
[HTML][HTML] Nucleophosmin: from structure and function to disease development
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of
pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability …
pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability …
The relationship between the nucleolus and cancer: Current evidence and emerging paradigms
The nucleolus is the most prominent nuclear substructure assigned to produce ribosomes;
molecular machines that are responsible for carrying out protein synthesis. To meet the …
molecular machines that are responsible for carrying out protein synthesis. To meet the …