Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide
low-affinity interaction interfaces. These compact modules play central roles in mediating …

Diurnal oscillations of gene expression controlled by the circadian clock and its connected
feeding rhythm enable organisms to coordinate their physiologies with daily environmental …

The cell nucleus contains a number of membrane-less organelles or intra-nuclear
compartments. These compartments are dynamic structures representing liquid-droplet …

Machine Learning is defined as a computer science discipline where algorithms iteratively
learn from observations to return insights from data without the need for programming …

The G-protein coupled receptor, metabotropic glutamate receptor 5 (mGluR5), is expressed
on both cell surface and intracellular membranes in striatal neurons. Using pharmacological …

Protein complexes carry out almost the entire signaling and functional processes in the cell.
The protein complex complement of a cell, and its network of complex–complex interactions …

Motivation: The determinants of kinase-substrate phosphorylation can be found both in the
substrate sequence and the surrounding cellular context. Cell cycle progression …

The transcription of rRNA is critical to all living cells and is tightly controlled at the level of
chromatin structure. Although the widespread adoption of genomic technologies including …

This chapter describes approaches for learning models of subcellular organization from
images. The primary utility of these models is expected to be from incorporation into complex …

Motivation: Protein kinases represent critical links in cell signaling. A central problem in
computational biology is to systematically identify their substrates. Results: This study …