Angiogenesis, the recruitment of new blood vessels, is an essential component of the
metastatic pathway. These vessels provide the principal route by which tumor cells exit the …

Often those diseases most evasive to therapeutic intervention usurp the human body's own
cellular machinery or deregulate normal physiological processes for propagation. Tumor …

We previously identified the angiogenesis inhibitor angiostatin. Using a similar strategy, we
have identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

1Angiogenesis is a fundamental process in reproduction and wound healing. Under these
conditions, neovascularization is tightly regulated. Unregulated angiogenesis may lead to …

Angiogenesis plays critical roles in human physiology that range from reproduction and fetal
growth to wound healing and tissue repair. The sophisticated multistep process is tightly …

Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that is able to
make normal endothelial cells unresponsive to a wide variety of inducers. Here we use both …

Targeted mutagenesis has allowed investigators to perform controlled experiments in
mammals and determine the contribution of individual proteins to physiologic and pathologic …

Increasing evidence suggests that carbohydrate-binding proteins play an essential role in
tumor growth and metastasis. However, conflicting results on their function in the regulation …

The urokinase plasminogen activator (uPA) system consists of the serine protease uPA, its
glycolipid-anchored receptor, uPAR and its 2 serpin inhibitors, plasminogen activator …