Genomics, convergent neuroscience and progress in understanding autism spectrum disorder

HR Willsey, AJ Willsey, B Wang… - Nature Reviews …, 2022 - nature.com
More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …

[HTML][HTML] The female autism phenotype and camouflaging: A narrative review

L Hull, KV Petrides, W Mandy - Review Journal of Autism and …, 2020 - Springer
Autism is more commonly diagnosed in males than females. One explanation is the 'female
protective effect': there is something inherent in being female which reduces the likelihood of …

[PDF][PDF] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders

PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

Advancing the understanding of autism disease mechanisms through genetics

L de la Torre-Ubieta, H Won, JL Stein… - Nature medicine, 2016 - nature.com
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

The inositol trisphosphate/calcium signaling pathway in health and disease

MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

[HTML][HTML] Sex differences in autism spectrum disorder: diagnostic, neurobiological, and behavioral features

A Napolitano, S Schiavi, P La Rosa… - Frontiers in …, 2022 - frontiersin.org
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a
worldwide prevalence of about 1%, characterized by impairments in social interaction …

What about the girls? Sex-based differences in autistic traits and adaptive skills

AB Ratto, L Kenworthy, BE Yerys, J Bascom… - Journal of autism and …, 2018 - Springer
There is growing evidence of a camouflaging effect among females with autism spectrum
disorder (ASD), particularly among those without intellectual disability, which may affect …

[HTML][HTML] Male sex bias in early and late onset neurodevelopmental disorders: Shared aspects and differences in Autism Spectrum Disorder, Attention Deficit …

S Santos, H Ferreira, J Martins, J Goncalves… - Neuroscience & …, 2022 - Elsevier
Neurodevelopmental disorders are characterized by relatively early onset, with temporal
variations across conditions. These lifelong conditions lead to social and communication …

Hippocampal GABAergic inhibitory interneurons

KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

[HTML][HTML] Sex/gender differences and autism: setting the scene for future research

MC Lai, MV Lombardo, B Auyeung… - Journal of the American …, 2015 - Elsevier
Objective The relationship between sex/gender differences and autism has attracted a
variety of research ranging from clinical and neurobiological to etiological, stimulated by the …