Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern
medicine. Effective prevention strategies are urgently required to slow the emergence and …

Background Sepsis and bloodstream infection are associated with significant morbidity and
mortality, and early effective antimicrobial therapy has been demonstrated to improve patient …

We carried out integrated host and pathogen metagenomic RNA and DNA next generation
sequencing (mNGS) of whole blood (n= 221) and plasma (n= 138) from critically ill patients …

Background Standard testing fails to identify a pathogen in most patients with febrile
neutropenia (FN). We evaluated the ability of the Karius microbial cell-free DNA sequencing …

Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA
has emerged as a promising diagnostic technology for bloodstream infections. However, a …

Bacteriophages, viruses that infect bacteria, have great specificity for their bacterial hosts at
the strain and species level. However, the relationship between the phageome and …

Metagenomic next-generation sequencing (mNGS) of microbial cell-free DNA (mcfDNA
sequencing) is becoming an attractive diagnostic modality for infectious diseases, allowing …

Metagenomic next-generation sequencing (mNGS) and droplet digital PCR (ddPCR) have
recently demonstrated a great potential for pathogen detection. However, few studies have …

Timely diagnosis remains an unmet need in non-neutropenic patients at risk for
aspergillosis, including those with COVID-19-associated pulmonary aspergillosis (CAPA) …

Background Plasma microbial cell-free DNA sequencing (mcfDNA-Seq) is a noninvasive
test for microbial diagnosis of invasive mold infection (IMI). The utility of mcfDNA-Seq for …