The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …

Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

Chromatin accessibility discriminates stem from mature cell populations, enabling the
identification of primitive stem-like cells in primary tumors, such as glioblastoma (GBM) …

Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that
sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts …

The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of
glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited …

Although the role of NOTCH signaling has been extensively studied in health and disease,
many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH …