A wide array of cell signaling mediators and their interactions play vital roles in
neuroinflammation associated with ischemia, brain trauma, developmental disorders and …

Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Nitric oxide (NO) has long been known as endothelium-derived relaxing factor. It is a
vasodilator, modulating vascular tone, blood pressure and hemodynamics, a role exploited …

Recent insights into the bioactivation and signaling actions of inorganic, dietary nitrate and
nitrite now suggest a critical role for the microbiome in the development of cardiac and …

Background—Because of global aging, the prevalence of heart failure with preserved
ejection fraction (HFpEF) continues to rise. Although HFpEF pathophysiology remains …

Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second …

PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of
drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
NO is a reactive oxygen species as well as a reactive nitrogen species. It is a free radical …

Natriuretic peptides (NPs) are a group of peptide-hormones mainly secreted from the heart,
signaling via c-GMP coupled receptors. NP are well known for their renal and cardiovascular …

Obesity has become a serious global health issue affecting both adults and children. Recent
devolopments in world demographics and declining health status of the world's population …