Peptide-based positron emission tomography probes: Current strategies for synthesis and radiolabelling

M Failla, G Floresta, V Abbate - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced
computerized tomography, and positron emission tomography (PET) are extensively …

Current status and future perspective of radiopharmaceuticals in China

J Hu, H Li, Y Sui, J Du - European Journal of Nuclear Medicine and …, 2022 - Springer
Radiopharmaceuticals are essential components of nuclear medicine and serve as one of
the cornerstones of molecular imaging and precision medicine. They provide new means …

First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma

X Duan, L Xia, Z Zhang, Y Ren, MG Pomper… - Clinical Cancer …, 2023 - AACR
Purpose: Nectin-4 is an emerging biomarker for cancer diagnosis and therapy. Recently,
enfortumab vedotin (EV) was approved by the FDA as the first nectin-4 targeting antibody …

Synthesis, Preclinical Evaluation, and First-in-Human PET Study of [68Ga]-Labeled Biphenyl-Containing PSMA Tracers

Y Chen, X Zhang, M Ni, X Gao, X Wang… - Journal of Medicinal …, 2023 - ACS Publications
Radioisotope-labeled prostate-specific membrane antigen (PSMA) PET tracers have gained
popularity in diagnosing prostate cancer (PCa). This study aimed to improve the affinity and …

Radiometallation and photo-triggered release of ready-to-inject radiopharmaceuticals from the solid phase

D Śmiłowicz, S Eisenberg, SH Ahn, AJ Koller… - Chemical …, 2023 - pubs.rsc.org
The efficient, large-scale synthesis of radiometallated radiopharmaceuticals represents an
emerging clinical need which, to date, is inherently limited by time consuming, sequential …

Landscape of nuclear medicine in china and its progress on theranostics

W Yang, F Kang, Y Chen, Z Zhu, F Wang… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Nuclear medicine in China started in 1956 and, with the rapid development of the economy
and continuous breakthroughs in precision medicine, has made significant progress in …

[HTML][HTML] Prostate specific membrane antigen positron emission tomography in primary prostate cancer diagnosis: first-line imaging is afoot

J Jiao, J Zhang, Z Li, W Wen, C Cui, Q Zhang, J Wang… - Cancer Letters, 2022 - Elsevier
Prostate specific membrane antigen positron emission tomography (PSMA PET) is an
excellent molecular imaging technique for prostate cancer. Currently, PSMA PET for patients …

Molecular Eye: A System for Precise Diagnosis and Treatment of Major Clinical Diseases Based on Molecular Probe Technology

X Ji, X Chen, K Li, Z Zhang, L Tang, T Li… - … & Biomedical Imaging, 2023 - ACS Publications
With the flourishing development of precision medicine, theranostics, generally recognized
as the integration of diagnosis and treatment, has emerged as a prominent trend in clinical …

Head-to-Head Comparison of 68Ga-PSMA-11 with 68Ga-P137 in Patients with Suspected Prostate Cancer

T Han, Z Quan, M Wang, X Meng, M Zhang… - Molecular …, 2023 - ACS Publications
P137 is a novel oxalyldiaminopropionic acid-urea-based prostate-specific membrane
antigen (PSMA) targeting agent. This study compared the uptake patterns of 68Ga-P137 and …

Development of a 18F-Labeled Bicyclic Peptide Targeting EphA2 for Molecular Imaging of PSMA-Negative Prostate Cancer

Q Gan, K Cui, Q Cao, N Zhang, MF Yang… - Journal of Medicinal …, 2023 - ACS Publications
Although PSMA PET/CT imaging has great potential for noninvasively detecting prostate
cancer (PCa), limitations exist for patients with low PSMA expression, caused by androgen …