Brain macrophage senescence in glioma

L Li, T Zhang, M Xiao, Y Lu, L Gao - Seminars in Cancer Biology, 2024 - Elsevier
Gliomas are a diverse group of primary central nervous system neoplasms with no curative
therapies available. Brain macrophages comprise microglia in the brain parenchyma, border …

Challenging the status quo to improve the translational potential of preclinical oncology studies

K Connor, A Golebiewska, AT Byrne - Nature Reviews Cancer, 2024 - nature.com
The precision medicine era has precipitated inherent new challenges to the preclinical
tumour biology field. Overall, continued poor clinical translatability of preclinical studies …

Understanding glioblastoma at the single-cell level: Recent advances and future challenges

YA Yabo, DH Heiland - PLoS biology, 2024 - journals.plos.org
Glioblastoma, the most aggressive and prevalent form of primary brain tumor, is
characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic …

[HTML][HTML] VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma

N Muñoz Perez, JM Pensabene, PM Galbo Jr… - Cancers, 2024 - mdpi.com
Simple Summary Immune checkpoint blockade has shown remarkable efficacy across
various cancers but has failed to improve outcomes in patients with relapsed …

[HTML][HTML] Protocol using ex vivo mouse brain slice culture mimicking in vivo conditions to study tumor growth and cell motility of glioblastoma cells

L Neises, C Delbrouck, A Schuster, M Rezaipour… - STAR protocols, 2024 - Elsevier
Herein, we present an ex vivo approach to study glioblastoma (GBM) cell motility in viable
mouse brain slice cultures, closely mimicking in vivo features. We detail the preparation and …

Dynamics of microglia-glioblastoma crosstalk at the far infiltration zone

FC Nebeling, F Fuhrmann, M Mittag, F Musacchio… - bioRxiv, 2024 - biorxiv.org
The interaction of glioblastoma (GB) and microglia is critical due to its implications for tumor
progression, immune response modulation, and potential therapeutic strategies. However …

Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs

M Dzwigonska, P Rosa, B Kaza, S Lipiec… - bioRxiv, 2024 - biorxiv.org
Hypoxia rapidly alters gene expression to allow cellular adaptation to challenging conditions
and support tumour growth. Hypoxia also affects the chromatin structure by modifications of …

Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcome

A Ellert-Miklaszewska, P Pilanc-Kudlek, K Poleszak… - bioRxiv, 2024 - biorxiv.org
Immune checkpoint inhibitors (ICI) presented clinical benefits in many cancer patients but
invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor …

7aaRGD-a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas

A Ellert-Miklaszewska, P Pilanc, K Poleszak, AJ Roura… - 2024 - researchsquare.com
Background Immune checkpoint inhibitors (ICIs) present clinical benefits in many cancer
patients but invariably fail in glioblastoma (GBM), the most common and deadly primary …