Brain macrophage senescence in glioma
L Li, T Zhang, M Xiao, Y Lu, L Gao - Seminars in Cancer Biology, 2024 - Elsevier
Gliomas are a diverse group of primary central nervous system neoplasms with no curative
therapies available. Brain macrophages comprise microglia in the brain parenchyma, border …
therapies available. Brain macrophages comprise microglia in the brain parenchyma, border …
Challenging the status quo to improve the translational potential of preclinical oncology studies
The precision medicine era has precipitated inherent new challenges to the preclinical
tumour biology field. Overall, continued poor clinical translatability of preclinical studies …
tumour biology field. Overall, continued poor clinical translatability of preclinical studies …
Understanding glioblastoma at the single-cell level: Recent advances and future challenges
YA Yabo, DH Heiland - PLoS biology, 2024 - journals.plos.org
Glioblastoma, the most aggressive and prevalent form of primary brain tumor, is
characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic …
characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic …
[HTML][HTML] VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma
N Muñoz Perez, JM Pensabene, PM Galbo Jr… - Cancers, 2024 - mdpi.com
Simple Summary Immune checkpoint blockade has shown remarkable efficacy across
various cancers but has failed to improve outcomes in patients with relapsed …
various cancers but has failed to improve outcomes in patients with relapsed …
[HTML][HTML] Protocol using ex vivo mouse brain slice culture mimicking in vivo conditions to study tumor growth and cell motility of glioblastoma cells
L Neises, C Delbrouck, A Schuster, M Rezaipour… - STAR protocols, 2024 - Elsevier
Herein, we present an ex vivo approach to study glioblastoma (GBM) cell motility in viable
mouse brain slice cultures, closely mimicking in vivo features. We detail the preparation and …
mouse brain slice cultures, closely mimicking in vivo features. We detail the preparation and …
Dynamics of microglia-glioblastoma crosstalk at the far infiltration zone
FC Nebeling, F Fuhrmann, M Mittag, F Musacchio… - bioRxiv, 2024 - biorxiv.org
The interaction of glioblastoma (GB) and microglia is critical due to its implications for tumor
progression, immune response modulation, and potential therapeutic strategies. However …
progression, immune response modulation, and potential therapeutic strategies. However …
Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs
M Dzwigonska, P Rosa, B Kaza, S Lipiec… - bioRxiv, 2024 - biorxiv.org
Hypoxia rapidly alters gene expression to allow cellular adaptation to challenging conditions
and support tumour growth. Hypoxia also affects the chromatin structure by modifications of …
and support tumour growth. Hypoxia also affects the chromatin structure by modifications of …
Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcome
A Ellert-Miklaszewska, P Pilanc-Kudlek, K Poleszak… - bioRxiv, 2024 - biorxiv.org
Immune checkpoint inhibitors (ICI) presented clinical benefits in many cancer patients but
invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor …
invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor …
7aaRGD-a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas
A Ellert-Miklaszewska, P Pilanc, K Poleszak, AJ Roura… - 2024 - researchsquare.com
Background Immune checkpoint inhibitors (ICIs) present clinical benefits in many cancer
patients but invariably fail in glioblastoma (GBM), the most common and deadly primary …
patients but invariably fail in glioblastoma (GBM), the most common and deadly primary …