NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

The complement membrane attack complex (MAC) is classically known as a cytolytic effector
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …

Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that
belong to the Ras‐like GTPase superfamily, and they can regulate vesicle trafficking. Rab …

Tumor suppressor activation or reactivation has long been a sought-after, yet elusive,
therapeutic strategy for human cancer. Phosphatase and tensin homolog (PTEN) is one of …

The ubiquitin‐proteasome system is a crucial mechanism for regulating protein levels in
cells, with substrate‐specific E3 ubiquitin ligases serving as an integral component of this …

The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse
models, primary human cells, and patient samples, we identified a T cell–autonomous role …

Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells,
such as macrophages, upon recognition of danger signals. Its secretion is regulated by the …

Background: Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific
antibodies, a factor contributing to chronic rejection and late allograft loss. Methods: We …

Internalization of complement membrane attack complexes (MACs) assembles NLRP3
inflammasomes in endothelial cells (EC) and promotes IL-β-mediated tissue inflammation …

Ras-related protein in brain (Rab) GTPases, the subfamily of small GTP-binding proteins
superfamily, play a vital role in regulating and controlling vesicles' transport between …