The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor
microenvironment (TME), where it can promote tumor progression or tumor suppression …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

The tumor microenvironment (TME) is a complex system composed of multiple cells, such as
non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Immortal spheroids were generated from fetal mouse intestine using the culture system
initially developed to culture organoids from adult intestinal epithelium. Spheroid proportion …

Functional interaction between neurons and glia is an exciting field that has expanded
tremendously during the past decade. Such partnership has multiple impacts on neuronal …

Recent research has indicated a new mode of intercellular communication facilitated by the
movement of RNA between cells. There is evidence that RNA can transfer between cells in a …

Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …