Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

One of the most important functions of skin is to act as a protective barrier. To fulfill this role,
the structural integrity of the skin depends on the dermal-epidermal junction—a complex …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

Dermal wounds, both acute and chronic, represent a significant clinical challenge, and
therefore the development of novel biomaterial-based skin substitutes to promote skin repair …

Physiologically‐relevant in vitro skin models hold the utmost importance for efficacy
assessments of pharmaceutical and cosmeceutical formulations, offering valuable …

Substrate stiffness (or rigidity) of the extracellular matrix has important functions in numerous
pathophysiological processes including fibrosis. Emerging data support a role for both a …

Skin substitutes for deep wound healing require meticulous designing and fabrication to
ensure proper structural and functional regeneration of the tissue. Range of physical and …

The effect of substrate stiffness on the cellular morphology, proliferation, and differentiation
of human mesenchymal stem cells (hMSCs) has been extensively researched and well …

Skin is exposed to a variety of potential stressors and stimulators that may impact
homeostasis, healing, tumor development, inflammation, and irritation. As such it is …

Vascular smooth muscle cell (VSMC) migration is a critical step in the progression of
cardiovascular disease and aging. Migrating VSMCs encounter a highly heterogeneous …