Epigenetic modifications work in concert with genetic mechanisms to regulate transcriptional
activity in normal tissues and are often dysregulated in disease. Although they are …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Microplastics (MPs) are a ubiquitous pollutant detected not only in marine and freshwater
bodies, but also in tap and bottled water worldwide. While MPs have been extensively …

Glucocorticoids are known to regulate protein metabolism in skeletal muscle, producing a
catabolic effect that is opposite that of insulin. In many catabolic diseases, such as sepsis …

Histone lysine methyltransferases (HMTs), a large class of enzymes that catalyze site-
specific methylation of lysine residues on histones and other proteins, play critical roles in …

SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-
DEAF1) domain-containing proteins (SMYD) have been found to methylate a variety of …

The protein lysine methyltransferase SET7 regulates DNA methyltransferase-1 (DNMT1)
activity in mammalian cells by promoting degradation of DNMT1 and thus allows epigenetic …

Estrogen receptor alpha (ERα) is a ligand-activated transcription factor. Upon estrogen
stimulation, ERα recruits a number of coregulators, including both coactivators and …

Smyd3 is a protein methyltransferase implicated in cancer development. Here we show that
Smyd3 expression in mice is required for chemically induced liver and colon cancer …

Histone methyltransferases and demethylases epigenetically regulate gene expression by
modifying histone methylation status in numerous cellular processes, including cell …