Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …

With the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, the middle
east respiratory syndrome CoV (MERS-CoV) in 2012 and the recently discovered SARS …

Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated
immunotherapies. Unfortunately, the molecular determinants are still poorly understood …

Although fibroblasts are dormant in normal tissue, they exhibit explosive activation during
wound healing and perpetual activation in pathologic fibrosis and cancer stroma. The key …

Metabolic reprogramming is a hallmark of cancer. Stromal cells could function as providers
of energy metabolites for tumor cells by undergoing the “reverse Warburg effect,” but the …

Background and purpose To compare 68 Ga-fibroblast activation protein inhibitor (FAPI) and
18 F-FDG PET/CT in imaging locally advanced oesophageal cancer, and evaluate the …

Abstract Tenascin-C (TNC), as a member of the extracellular matrix (ECM), plays an
important role in cancer cell proliferation and migration and tumor invasion in various types …

Bidirectional communication between cells and their microenvironment is crucial for both
normal tissue homeostasis and tumor growth. During the development of oral tongue …

Background Markers of stromal activation at future metastatic sites may have prognostic
value and may allow clinicians to identify and abolish the pre-metastatic niche to prevent …

In the last years, the extracellular matrix (ECM) has been reported as playing a relevant role
in esophageal cancer (EC) development, with this compartment being related to several …