The glycosylation of cell surface receptors has been shown to regulate each step of signal
transduction, including receptor trafficking to the cell surface, ligand binding, dimerization …

Most of membrane molecules including cell surface receptors and secreted proteins
including ligands are glycoproteins and glycolipids. Therefore, identifying the functional …

This review is the eighth update of the original article published in 1999 on the application of
Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …

It is well established that the epidermal growth factor (EGF) receptor, receptor tyrosine-
protein kinase erbB-2 (ERBB2)/human EGF receptor 2 (HER2), and, to a lesser extent …

Abstract Surfactant protein D (SP-D) is a member of the collectin family that has an important
role in maintaining pulmonary homeostasis. In this study, we demonstrated that SP-D …

MET, the receptor for the hepatocyte growth factor (HGF), is strongly associated with
resistance to tyrosine kinase inhibitors, key drugs that are used in the therapy of non–small …

Glycans found on receptor tyrosine kinases (RTKs) have emerged as promising targets for
cancer chemotherapy, aiming to address issues such as drug resistance. However, to …

Numerous signal-transduction-related molecules are secreted proteins or membrane
proteins, and the mechanism by which these molecules are regulated by glycan chains is a …

N-glycosylation and proper processing of N-glycans are required for the function of
membrane proteins including cell surface receptors. Fibroblast growth factor receptor …

Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth
factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were …