Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

High Density Lipoprotein (HDL) particles, beyond serving as lipid transporters and playing a
key role in reverse cholesterol transport, carry a highly variable number of proteins, micro …

The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to
either signal through intracellular targets or to activate a family of specific G-protein-coupled …

Low plasma levels of high-density lipoprotein (HDL) cholesterol are associated with
increased risks of coronary heart disease. HDL mediates cholesterol efflux from …

The survivor activating factor enhancement (SAFE) pathway was discovered as an
alternative intrinsic pro-survival signaling pathway to the reperfusion injury salvage kinase …

Ischemic diseases in an aging population pose a heavy social encumbrance. Moreover,
current therapeutic approaches, which aimed to prevent or minimize ischemia-induced …

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid contained in High-density
lipoproteins (HDL) and has drawn considerable attention in the lipoprotein field as …

Hyperlipidaemia is a well‐established risk factor for cardiovascular diseases and therefore,
many animal model have been developed to mimic the human abnormal elevation of blood …

The cholesterol concentrations of low-density lipoprotein (LDL) and high-density lipoprotein
(HDL) have traditionally served as risk factors for cardiovascular disease. As such, novel …

High-density lipoprotein (HDL) and its principal apolipoprotein AI (ApoA-I) have now been
convincingly shown to influence glucose metabolism through multiple mechanisms. The key …